Guddu and Golu kickstart the business again, but are still looking for a supply of opium which would allow them to establish control over Purvanchal's underworld. In the hunt for the same control, Sharad tries to crack a deal with one of Guddu's old allies, while Madhuri tries to eliminate Guddu.

Guddu cements his power over Mirzapur while Sharad finally makes a very strong ally. Golu receives a threat from Bharat. Ramakant turns down Robin's offer and faces danger in prison. Meanwhile Madhuri strategises to bring Guddu down in other ways.

Purvanchal is set ablaze with a gang war between Sharad and Guddu. Madhuri makes strong decisions to break the police-gangster nexus, while a ghost from the past resurfaces. Ramakant finds a purpose in prison, which catches Lala's attention.

Guddu goes down a dark downward spiral as he loses people close to him. A new judge is assigned before Ramakant's final hearing. Meanwhile, Saloni discovers her husband's secrets. IG Dubey is reinstated and is tasked with one mission: Capturing Guddu Pandit.