Guddu and Golu kickstart the business again, but are still looking for a supply of opium which would allow them to establish control over Purvanchal's underworld. In the hunt for the same control, Sharad tries to crack a deal with one of Guddu's old allies, while Madhuri tries to eliminate Guddu.

Guddu cements his power over Mirzapur while Sharad finally makes a very strong ally. Golu receives a threat from Bharat. Ramakant turns down Robin's offer and faces danger in prison. Meanwhile Madhuri strategises to bring Guddu down in other ways.

Purvanchal is set ablaze with a gang war between Sharad and Guddu. Madhuri makes strong decisions to break the police-gangster nexus, while a ghost from the past resurfaces. Ramakant finds a purpose in prison, which catches Lala's attention.

Golu returns to Mirzapur only to discover the chaos that ensued in her absence. Madhuri inaugurates Aam Bagh despite the threat of JP Yadav looming large. As Dussehra closes in, there is only one question: Who will ascend the throne of Mirzapur?