After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

Maggie and OA hunt down a ruthless group of robbers who are posing as police officers to target armored trucks.

After an investigative journalist is murdered, the team uncovers information linking the suspect to past cases. The victim’s death also strikes a chord with Maggie, leaving her desperate for answers in regard to a traumatic event in her personal life.

A serial bomber appears to be targeting Wall Street’s elite. Maggie and OA search for a suspect who seems dead-set on revenge, while Dana deals with Spencer Briggs, a cocky profiler brought in to consult on the case.

When a controversial senior leader from Egypt comes to New York for a heart transplant, OA struggles to balance his personal opinion with his professional duty when he is assigned to the security detail.

After a front-running female presidential candidate, Valerie Caldwell, is targeted with a car bomb, OA and Maggie must hurry to track down the bomber before they strike again. The case leads them to wonder whether this person is targeting Caldwell for her political aspirations or something else.

The team welcomes a new member, Special Agent Tiffany Wallace, as they search for killers who orchestrated a mass shooting at a media company, and OA’s personal connection with the case threatens to cloud his judgement.

When the leader of a drug cartel and one of the world's most wanted men, Antonio Vargas, is apprehended by the team, the entire FBI headquarters is put at risk when his henchmen unveil a terroristic threat to free him. During the turmoil, Isobel must make the difficult decision whether to sacrifice her conscience or her career.

The team must infiltrate a drug trafficking gang after the robbery of a chemical plant leaves two customs agents dead. Also, Nestor offers his help on the case, giving Maggie new insight into his character.

When five prominent men are killed at a trendy New York City restaurant, the team’s investigation brings them into contact with a lieutenant in Antonio Vargas’ cartel, triggering a long-awaited showdown between Isobel and Vargas.

The team finds a connection between bombings and a private veterans' club in New York City; Isobel tells a reluctant OA to recruit a former Army buddy for intel.

OA is forced to confront one of his biggest fears when the team discovers that deadly sarin gas may have been sold to terrorists.

The team investigates the murder of a professional informant after he's found dead outside an abandoned factory in Red Hook. Also, Maggie reconnects with an old colleague and mentor.