When the leader of a drug cartel and one of the world's most wanted men, Antonio Vargas, is apprehended by the team, the entire FBI headquarters is put at risk when his henchmen unveil a terroristic threat to free him. During the turmoil, Isobel must make the difficult decision whether to sacrifice her conscience or her career.

The team must track down two assailants who wear animal masks while committing armed robberies, with the latest leaving an off-duty 26 Fed security guard dead. Also, Tiffany and Scola butt heads on whether or not to accept the local NYPD’s offer to help in the investigation.

When an officer is shot dead at a pawn shop along with the store’s owner, the team tries to figure out why a young, recent Ivy League dropout is tied to the crime.