When the leader of a drug cartel and one of the world's most wanted men, Antonio Vargas, is apprehended by the team, the entire FBI headquarters is put at risk when his henchmen unveil a terroristic threat to free him. During the turmoil, Isobel must make the difficult decision whether to sacrifice her conscience or her career.

The team rushes to track down two doctors abducted by a desperate father willing to do anything to save his son. Also, Jubal's uncertainty in his family life affects his judgement during the hostage situation.

When a young couple is found murdered in a New York City park after returning from vacation, the team searches for a suspect linked to the drug trade. Also, Scola turns over a new leaf when it comes to his relationships.

When a deadly truck heist arms the killers with enough ammonium nitrate to construct a massive bomb, the team discovers a link to a terrorist group Maggie is working to infiltrate.

When a prominent doctor is found dead in a ritualistic slaying, the team must race against time to hunt down a religiously motivated serial killer. Also, Scola faces a life-or-death decision.

When a retired FBI agent is tortured and killed while working a security job, Scola and Nina go undercover as a married couple deep in the diamond game as the team tries to find out who is responsible. During the course of his and Nina's dangerous assignment, Scola is plagued by the possibility that their son Doug could end up parentless.