Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.

Max navigates his diagnosis while Dr. Sharpe encourages him to make a plan. Meanwhile, Dr. Bloom encourages Reynolds to take a chance and Dr. Kapoor and Iggy work together to help a child.

Reynolds begins to build his department as Dr. Sharpe battles skepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.

Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.

Max faces the pressure of his first fundraising gala at the hospital; Frome struggles to break difficult news to his daughter; Bloom and Reynolds deal with the fallout of their argument; Kapoor and Sharpe work to help a sick father and son.

With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.

Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.

As Max fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. As the team feels Max's absence and the doctors find out that they may have to treat one of their own, Sharpe must finally come clean about Max's condition.

Tensions are high in the hospital as Bloom is overruled on a diagnosis. Meanwhile, Iggy notices that something may be amiss with one of the hospital's most respected surgeons.

Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds has difficulty handling a personal matter regarding a patient's family and Iggy struggles with a realization regarding his daughter.

Sharpe works on a creative way to help Max and Kapoor gets surprising news. Meanwhile, Reynolds takes a big step in his relationship with Evie as one of the doctors makes a life altering decision.

Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.

Max invokes a hospital-wide census in effort to get to know the staff of New Amsterdam on a deeper level. Reynolds takes a leap of faith that lands him in hot water, and Dr. Castro extends her treatment plan to more patients in the hospital.

When Sharpe has a case that hits close to home, she and Max team up to make things right for the patient. Meanwhile, Iggy and Bloom are forced to make a tough call on a unique situation.

When Kapoor introduces a patient to Iggy's PTSD group, a creative treatment plan causes turmoil. Sharpe discovers a long-kept secret regarding a patient.

Sharpe lands in hot water when she goes out on a limb for a patient. Max's grief comes to a head. Bloom takes a major step in her recovery.

When an inmate comes in with an entirely preventable illness, Max, Sharpe, and Iggy head directly to the source - Rikers Island. Meanwhile, Bloom struggles with her recovery, and Reynolds gets news that could change his life.