When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.

When Kapoor introduces a patient to Iggy's PTSD group, a creative treatment plan causes turmoil. Sharpe discovers a long-kept secret regarding a patient.

When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.

Max resists an idea that could bring New Amsterdam more revenue. Iggy pushes back on the new telemedicine system. Sharpe uncovers a startling trend while treating a beloved former patient.

Max is on a mission to fix systemic racism at New Amsterdam. Bloom treats a patient who reminds her that things aren't as they seem. Sharpe is overwhelmed while tending to a family matter. Reynolds tries to keep his composure while treating a father and son.

Sharpe offers help to a reluctant Mina. Max is faced with a tough decision about Luna. Bloom and Casey treat a patient who has been hiding a lifelong secret. Iggy finds himself in a very dangerous predicament. Reynolds treats a young heart transplant patient with astonishing symptoms.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where had sought refuge; Sharpe and Malvo assist a patient with a life threatening condition; Reynolds is conflicted about his new position.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.