Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.

Max faces the pressure of his first fundraising gala at the hospital; Frome struggles to break difficult news to his daughter; Bloom and Reynolds deal with the fallout of their argument; Kapoor and Sharpe work to help a sick father and son.

Sharpe struggles when a case hits too close to home. Frome uncovers a patient's surprising past. Reynolds makes progress in his personal life after some difficult news.

When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.

Sharpe lands in hot water when she goes out on a limb for a patient. Max's grief comes to a head. Bloom takes a major step in her recovery.

Max, Bloom and Reynolds frantically recount a patient's past encounter that could throw them into a massive lawsuit. Meanwhile, Iggy confronts a local middle school about its teaching policies, and Kapoor lets his superstitions take over.

New Amsterdam is still reeling from the pandemic as a plane crash lands in the East River. When investigators come to interrogate the flight crew, Iggy fights against the clock to help the pilot uncover the truth. Max tracks down scarce medication after one of his own contracts COVID.

Max journeys to Connecticut to bring Luna back to New York, but second-guesses his instincts when he sees her with her grandparents. Bloom takes action to ensure her staff feel safe at work while Reynolds takes a backseat in the cardiac unit. Sharpe struggles to lean on Dr. Cassian Shin while dealing with a family emergency.

When Sharpe notices the hospital's blood supply is running dangerously low, Max concocts a plan to get New Amsterdam out of trouble. Reynolds realizes he has a thing or two to learn from Bloom while making peace with his new position. Iggy helps a patient face their inner demons.

A burst pipe plunges the ED into chaos. Iggy counsels two stressed out parents about their child. Gwen and Calvin have some devastating news for Max.

Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation at the hospital. Bloom begins a tricky dynamic with her new Emergency Department residents. Reynolds finds himself in an awkward position with Dr. Baptiste and his wife, Dr. Lyn Malvo.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED. Iggy gets a lesson in humility. Brantley has a surprise for the staff.

Helen takes the reins at NHS Hampstead Hospital while Max gets creative to help a patient in need. Reynolds reaches a decision about Dr. Malvo. Iggy and Bloom help their patients understand the underlying cause of their stress. Dr. Wilder employs more unconventional techniques.

Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen’s decision. Bloom gives extra space to Leyla, but she’s in for a surprise. Reynolds and Wilder help a young terminal patient realize his dream to star in a Bollywood show. Iggy has a breakthrough with a challenging patient.

Max discovers a revenue-generating department at the hospital that has serious legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats a truly inspirational patient and makes plans for his father. Wilder's young patient teaches her not to jump to conclusions in diagnosing.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.