Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.

Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.

With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.

Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.

When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.

Max is forced to reckon with his diagnosis in a new way as things become more difficult for him. Meanwhile, Reynolds is forced to address what could have gone wrong in a recent surgery.

Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.

Max invokes a hospital-wide census in effort to get to know the staff of New Amsterdam on a deeper level. Reynolds takes a leap of faith that lands him in hot water, and Dr. Castro extends her treatment plan to more patients in the hospital.

Max takes a chance on a new assistant and goes toe-to-toe with the board on a new plan; Iggy struggles to figure out what is causing a unit-wide illness; Kapoor receives some shocking news.

Sharpe has an important realization that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.

Max races against the clock to rearrange the budget when faced with employees going unpaid, while Kapoor is presented with a device that's the future of medicine. Meanwhile, Iggy goes against the norms to prove a diagnosis and Bloom gets an unexpected visitor.

When tasked with turning the opioid epidemic around, Max shuts down the ED and proposes a massive change. Meanwhile, Sharpe goes great lengths to prove a point.

Max searches for a solution to crowdfunding after his eye-opening appearance in a viral "Go Fund Me" video. Reynolds takes his last laps at the hospital while Kapoor helps a former pilot deal with his life as a paraplegic.

New Amsterdam is still reeling from the pandemic as a plane crash lands in the East River. When investigators come to interrogate the flight crew, Iggy fights against the clock to help the pilot uncover the truth. Max tracks down scarce medication after one of his own contracts COVID.

Max is forced to face the heartbreaking consequences of one of his policies. Bloom comes to a startling realization about Iggy.

When Sharpe notices the hospital's blood supply is running dangerously low, Max concocts a plan to get New Amsterdam out of trouble. Reynolds realizes he has a thing or two to learn from Bloom while making peace with his new position. Iggy helps a patient face their inner demons.

Max is on a mission to fix systemic racism at New Amsterdam. Bloom treats a patient who reminds her that things aren't as they seem. Sharpe is overwhelmed while tending to a family matter. Reynolds tries to keep his composure while treating a father and son.

Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation at the hospital. Bloom begins a tricky dynamic with her new Emergency Department residents. Reynolds finds himself in an awkward position with Dr. Baptiste and his wife, Dr. Lyn Malvo.

Max and Sharpe go public with their relationship at the hospital. The team struggles to handle an overcrowded and understaffed ICU. Iggy's overly critical feedback alienates his residents.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED. Iggy gets a lesson in humility. Brantley has a surprise for the staff.

Dr. Reynolds and Dr. Malvo have a heart-to-heart with Dr. Baptiste. Max learns a little more about Sharpe when someone from her past resurfaces. Iggy plays referee between two young patients and their families. Dr. Wilder reconsiders Max’s offer to join the staff.

Max and Bloom are shocked when a deadly ambulance crash reveals a dangerous plan. Dr. Fuentes pressures Iggy to take on patients. Sharpe realizes her own cost-cutting has adversely affected her department. Reynolds, Baptiste and Malvo strive to reach an accord.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

As the team gathers to mourn the loss of someone dear, Max and Helen realize the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision while Reynolds decides to take his concerns for his patients to a new level. Dr. Fuentes once again reminds the New Amsterdam team who is in control.

Max formulates a bold plan to help New Amsterdam before it’s too late. Reynolds and Dr. Fuentes fight over the best way to handle a risky surgery. Dr. Wilder asks Dr. Castries for help with a patient with terminal cancer. Iggy helps a father and son deal with vastly different views on a shared trauma.

The New Amsterdam team goes out for a night of karaoke and drinking, but must face the consequences at work the next day. Iggy helps a mysterious patient confront a past trauma. Reynolds and Dr Malvo discuss their future. Leyla gives Lauren some bad news.

Max discovers the extent to which Dr. Fuentes' cuts are severely damaging New Amsterdam and decides it's now or never. Iggy takes an unconventional approach to reach a young patient in need. Reynolds and Wilder perform a risky, life-saving surgery on unborn twins.

As a monster hurricane approaches New York, Bloom and the team scramble to put preparations in place. Max and Helen make plans for an intimate New York wedding as she returns from London. Iggy and Martin reach a crossroads. Reynolds finally makes contact with his father.

Max tests a bold new cost-saving program that could help both New Amsterdam and its neediest patients. Wilder struggles with a patient’s decision to refuse life-saving surgery. Reynolds comes to an important realization about his father’s behaviors. Iggy takes the leap into online dating.

The New Amsterdam staff grapple with the aftermath of the recent Supreme Court decision on abortion rights. Wilder counsels a woman whose pregnancy puts her life in danger. At Brantley's urging, Max endeavors to find a healthcare solution for out-of-state patients. Bloom reveals monumental news to Reynolds.

Max discovers a revenue-generating department at the hospital that has serious legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats a truly inspirational patient and makes plans for his father. Wilder's young patient teaches her not to jump to conclusions in diagnosing.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.