In March 2000, 71-year-old Margarita Ruiz and her adult daughter Hope are senselessly murdered. Detectives and relatives are stunned and the case goes unsolved for six years. Then, fortuitously, a puzzling phone call from 1500 miles away leads investigators to the killer.

A young mother is brutally murdered in her own home, and her family is shot and left for dead.

On an evening in March of 1990, a knock comes at the door of Donna Willard's Philadelphia residence, and she finds herself face-to-face with a hooded gunman. He shoots Donna twice, killing her instantly, as her twelve-year-old son witnesses the murder from the peak of the stairs. For months, the hunt for her killer leads investigators on a maddening series of dead ends.

It's late as 26-year-old student Tracey Schoettlin finishes her serving shift at a restaurant in downtown Birmingham, Alabama. She clocks out but never makes it home. The next day, her body is found beneath a bridge with 19 stab wounds, igniting a panic throughout the city and in the media. Investigators have no credible leads and the case goes cold. Then eight months later, a man shows up and reports to police his mystical visions from God about the brutal murder.

December 23, 1981, is supposed to be a happy day for Roxann Jeeves and her son, Kristopher. It's the boy's fifth birthday and they have plans to tour a candy factory. Instead, the day ends in unthinkable tragedy. Mother and son are brutally murdered together in a field outside Dallas, Texas. Their killer flees the scene and the investigation ultimately goes cold, but the killer leaves evidence that leads Detective Larry Forsyth on an epic 20-year hunt.

An everyday teenage girl is found murdered in the Arizona desert upon Christmas Eve, 1988. Detectives soon studious her say, Cindy Monkman Apelt, who was reported missing by her husband the night prior. As investigators painstakingly fragment together an account of Cindy's sealed hours, they concern closer and closer to revealing her killer. Prosecutor Anna-Sigga Nicolazzi revisits the shocking crime behind the detectives and disclose attorney who solved the lawsuit and ultimately won justice for Cindy's associates.

After computer whiz Cari Farver goes missing, she starts sending threatening text messages to her new boyfriend, his ex-lover and her mother; it's up to the police to determine if she's a deranged stalker or a murder victim.

Young mother Tyshika Askins is found strangled to death in her home; after charging the wrong man, police realize the key to solving the case lies in an orange juice container left out on a kitchen counter.

Las Vegas police hunt for the monster who raped and murdered a high school sophomore before he strikes again.

A 59-year-old grandmother is discovered beaten and stabbed to death in her home on Mother's Day.

In Pensacola, Fla., a beloved barber is gunned down in his shop in broad daylight; DNA left at the crime scene may hold the answer to solving this murder mystery.

Penske Racing chef Cindy Albrecht goes missing from her home near the Indianapolis Motor Speedway in Speedway, Ind., then her headless body is later found by deer hunters.

After grandmother Irene Kennedy is found dead in a park, a distant relative is charged with her murder, splitting her family apart; it will take years, another killing and a jail house snitch to bring the family back together.

Young mother Nancy Klinger goes missing after telling friends she's working undercover on a black-market baby sting.

A 19-year-old convenience store clerk vanishes in Sheridan, Wyo.; a gruesome discovery seems to point police to a cold-blooded killer.

Anna-Sigga Nicolazzi meets with the detective and prosecutor who took on the case of Karen Ann Watson, a wife and mother who was brutally stabbed to death in 1987; nearly 30 years later, they track down a killer who thinks he got away with murder.

The town of Indiana, Pennsylvania, is rocked by the murder of Theresa Dalessio. Shot at home with her family nearby, the crime is confounding. Theresa has no obvious enemies, but as evidence emerges, suspects are revealed - including her own husband.

A crime wave is sweeping Boston and police resources are stretched thin. The murder of a single mother is on the brink of becoming just another number in a wave of unsolved homicides. As the case goes cold for years, a toddler is left without his mom and an immigrant family faces an overwhelming justice system they can barely comprehend. Then, the nation’s top cold case duo attempts to catch her killer. They develop a technique that would change investigative procedure forever hoping to secure justice for a mother gone too soon.

Armed with homemade bombs, a group of masked gunmen ambush a family in the middle of the night, and murder a teenage daughter and her mom. The family’s tragedy is worsened when they believe that one of their own loved ones was behind the double homicide. It would take 30 years and an eager state trooper to bring the killer to justice.

The innocence of the quiet, rural town of Miles City, Montana is shattered when a doting father of two and loving husband, Marty Etchemendy, disappears after a local football game. The Sheriff and local volunteers scour the dusty countryside for any sign of the missing father. The trail leads detectives out of Montana on a life-and-death chase spanning over 150 miles. Investigators hold on hard to hope, but will the intense manhunt for a hostage turn into a search and recovery?

When a beloved elderly couple is stabbed over 60 times each in their bed, local law enforcement work with the FBI to track down a twisted killer. The gruesome details shock a quiet town, while the investigation sparks a rift within the victims’ families.

A young father is gunned down right outside his mother’s home, and the murder is captured on security cameras. Investigators analyze surveillance video and hours of recorded calls to uncover a murder plot that threatens the entire justice system. But before the case goes to trial, prosecutors get word that the savvy killer ordered a hit against them. Now, they too, are caught in the crosshairs of danger.

Diana Duve had it all: great friends, supportive family, a fulfilling career, and a charismatic, successful boyfriend. But when she mysteriously goes missing, the resulting investigation unearths a past riddled with vitriol and violence. They discover a wake of victims and a heinous escalation of abuse. The prosecution knows they need to expose this wolf in sheep’s clothing before he can kill again.

Horse grooms at a racetrack find one of their own dead in her dorm. Her death is ruled a suicide, but her family suspect foul play. Three years later, the original investigator gets a tip about an eerily similar death 1400 miles away. Can this suicide be turned into a homicide case? A detective who won’t give up hope, tries to the connect the two and bring closure to the families of these victims.

When a well-known local cabby, famous for his generosity, is found shot to death in his car in Peekskill, NY, the whole city wonders how this happened. The Peekskill police force and a Westchester County’s dogged prosecutor deploy every resource available to track a killer. And within 48-hours, their rapid-fire investigation uncovers a treacherous plot hatched in a deadly love affair.

There’s no pain like the loss of a young, innocent life. When a 14-year-old’s murder goes unsolved for decades, it festers into a wound that never heals. The family had long since given up hope. But everything changed when a cold case detective made it his mission to find closure for the small town that’d been plagued by questions and distrust for over 30 years.

Two generations of a family endure the tragedy of big city gun violence.

Two murders on Long Island, New York, set off a multi-county manhunt.

The disappearance of a 21-year-old sparks a massive mobilization of law enforcement to delve into the world of digital forensics.

When 12-year-old Naomi Jones goes missing, her mother sounds the alarm, triggering a massive search effort. But when they discover her body a few miles from her home, a team of investigators sets out to find the heartless killer who took her life.

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A simple break in routine leads to the discovery of a murdered grandfather and a missing child. Investigators must contend with a devious killer who's taken pains to cover their tracks to unravel this tragic tale of lies and betrayal.

The mysterious disappearance of Bruce Blackwood becomes a dominant missing persons case until a veteran investigator and a young prosecutor team up on a mission to deliver justice. It's a tall order until a late night bombshell breaks the case wide open.

Callous killers gun down a young mother out on a stroll, and deceit masks their trail.