Karamatsu tries to take on various requests from everyone to look like a reliable brother, only to take on more than he can handle, so Choromatsu tries to teach him how to refuse. Totoko begins working at a company, proving to be a handful for her superior Todomatsu. Later, a pair of seiyuu attend a dubbing session of an episode of Mr. Osomatsu, witnessing how the sextuplets do their work.

Jyushimatsu befriends a young boy named Eitarou but gets called in by Eitarou's mother when he starts imitating him. Later, Dayon steals Dekapan's underwear, forcing him to give chase all over the city and universe while butt naked.

A group of aliens pursue the legendary space pirate, Shazarr. Later, displeased with Chibita's oden, Matsuzou serves up his own brand of the dish. Finally, the sextuplets become enamored by their new neighbor, Kinko Inuyama, prompting jealousy from Totoko when they go on a date with Kinko instead of her.

In the 1960s, Iyami comes across a blind flower girl named Okiku and, despite being poor himself, tries to help her raise money for eye surgery.

After Dekapan becomes president, his secretary Todomatsu tries to keep him from pressing the Big Red Button. Iyami attempts to pull off a sham ventriloquism scheme by having Chibita and Hatabou act as his puppets. On Valentine's Day, the brothers try in vain to get some Valentine's chocolate from someone.

The brothers get rowdy while getting drunk at a restaurant. Unemployed office lady Totomi ends up taking a job at a strange establishment that offers some peculiar services. After being visited by a salesman, Matsuyo contemplates sending off one of her sons to a NEET correctional facility, asking Choromatsu to help her decide which one to send away.

Matsuzou becomes hospitalized, leading the brothers to seriously think about their lives and get proper jobs to support their family. A chance meeting with Totoko sets Osomatsu's mind straight...