Karamatsu tries to take on various requests from everyone to look like a reliable brother, only to take on more than he can handle, so Choromatsu tries to teach him how to refuse. Totoko begins working at a company, proving to be a handful for her superior Todomatsu. Later, a pair of seiyuu attend a dubbing session of an episode of Mr. Osomatsu, witnessing how the sextuplets do their work.

A group of aliens pursue the legendary space pirate, Shazarr. Later, displeased with Chibita's oden, Matsuzou serves up his own brand of the dish. Finally, the sextuplets become enamored by their new neighbor, Kinko Inuyama, prompting jealousy from Totoko when they go on a date with Kinko instead of her.

After Dekapan becomes president, his secretary Todomatsu tries to keep him from pressing the Big Red Button. Iyami attempts to pull off a sham ventriloquism scheme by having Chibita and Hatabou act as his puppets. On Valentine's Day, the brothers try in vain to get some Valentine's chocolate from someone.

The brothers get rowdy while getting drunk at a restaurant. Unemployed office lady Totomi ends up taking a job at a strange establishment that offers some peculiar services. After being visited by a salesman, Matsuyo contemplates sending off one of her sons to a NEET correctional facility, asking Choromatsu to help her decide which one to send away.

Osomatsu and the rest take off for a wonderful Hawaiian vacation, only for disaster to strike, crashing Hatabou's private jet somewhere in the Pacific. How will our strange company survive the terrible desert island wilderness?