The Matsuno brothers try to adapt their show to contemporary times, with mixed results.

Wanting to become the main protagonist of the franchise again, Iyami holds a bizarre kart race to determine who the protagonist of Osomatsu-san will be.

The 10-year-old Matsuno sextuplets of Osomatsu-kun are given a glimpse of the future and see they're going to get fat, greedy and beaten up by angry girls.

The prehistoric sextuplets return, partaking in dangerous sports. Later, in modern day, noticing their father acting strangely, the brothers discover that he is worried that there's not enough spark in his marriage. Feeling he should return to a more innocent time, the boys give their old man a masterclass in being a virgin, albeit with no success. After embarrassing himself in front of his sons, Matsuzou considers a love potion from Dekapan, but is this really the best way to patch things up with the love of his life?

Jyushimatsu befriends a young boy named Eitarou but gets called in by Eitarou's mother when he starts imitating him. Later, Dayon steals Dekapan's underwear, forcing him to give chase all over the city and universe while butt naked.

In the 1960s, Iyami comes across a blind flower girl named Okiku and, despite being poor himself, tries to help her raise money for eye surgery.

The brothers get rowdy while getting drunk at a restaurant. Unemployed office lady Totomi ends up taking a job at a strange establishment that offers some peculiar services. After being visited by a salesman, Matsuyo contemplates sending off one of her sons to a NEET correctional facility, asking Choromatsu to help her decide which one to send away.

Osomatsu and the rest take off for a wonderful Hawaiian vacation, only for disaster to strike, crashing Hatabou's private jet somewhere in the Pacific. How will our strange company survive the terrible desert island wilderness?

The Matsunos and Iyami are killed in a freak plane crash, sending them to Hell. In mourning, the others ponder a way to bring the status quo back to its rightful place with the help of someone near and dear to them.