Jyushimatsu befriends a young boy named Eitarou but gets called in by Eitarou's mother when he starts imitating him. Later, Dayon steals Dekapan's underwear, forcing him to give chase all over the city and universe while butt naked.

The brothers get rowdy while getting drunk at a restaurant. Unemployed office lady Totomi ends up taking a job at a strange establishment that offers some peculiar services. After being visited by a salesman, Matsuyo contemplates sending off one of her sons to a NEET correctional facility, asking Choromatsu to help her decide which one to send away.

The Matsunos and Iyami are killed in a freak plane crash, sending them to Hell. In mourning, the others ponder a way to bring the status quo back to its rightful place with the help of someone near and dear to them.

Osomatsu-san returns in an all-new family-friendly incarnation! Surely nothing will go wrong, right?