Ichimatsu gets a job interview at a cat cafe, but when in Rome, he does as the locals do. Later, in an apocalyptic world, F6 battles against Iyami and Dekapan, who are robbing the dry-skinned citizens of all of their lotion. After, Ichimatsu is forced to pretend to be Karamatsu after Osomatsu catches him trying on his clothes.

Osomatsu-san returns in an all-new family-friendly incarnation! Surely nothing will go wrong, right?

Choromatsu, Todomatsu, and Ichimatsu discuss their expectations for the show's third season. Hatabou struggles to deliver an online food order. The sextuplets harass a touchy couple. Totoko plays an awful but beautiful doctor. Jyushimatsu and Karamatsu hang out in a konbini and find a strange ad. Two robots powered by AI arrive at the Matsuno home.