Sara and Moore return to the killer's abandoned house in search of new information about their suspect. Kreizler faces ruin after a tragic incident at the Institute. Sara and the team are enlisted to rescue another missing child.

While Sara, Moore and Kreizler struggle with decisions about their future paths, New York is in the grips of an all-out manhunt for the killer, and the team must overcome the wrath of the police and an underworld gang on the rampage.