9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.

When George Sr. is rushed to the emergency room, Connie comes to babysit, and the kids have an adventure getting to the hospital on their own.

A worried Mary sends Sheldon to Sunday school after she finds him playing Dungeons and Dragons with his friends, Tam and Billy.

When Mary takes a job as church secretary, she finds herself becoming Pastor Jeff's marriage counselor. Also, Sheldon and Missy spend their first afternoon home alone.

A battle erupts between the Coopers and Sparks when the Sparks' new dog terrorizes Sheldon.

When Mary’s faith is shaken by a tragedy in the community, Sheldon becomes an unlikely ally.

Mary clashes with Sheldon's drama teacher over plans for a Halloween fundraiser for the church. Georgie falls for a rebellious teenage girl whom Sheldon is tutoring.

Sheldon experiments on Missy, and Georgie joins Mary’s bible study to spend more time with his crush, Veronica.

Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks a question wrong on Sheldon's test. Also, Mary takes over for Pastor Jeff when he's out sick.

Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.

Inspired by his hero, Albert Einstein, Sheldon tries his hand at the violin. Also, Mary and Connie secretly buy a pregnancy test when Mary thinks she's pregnant

Unhappy that school funds are going towards football rather than academics, Sheldon decides to run for class president.

The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.

Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.

A church carnival leads Missy to try out for the baseball team. Also, Connie struggles after her breakup with Dr. Sturgis.

The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Connie's new boyfriend, and Mary is determined to rid her home of greed.

Mary gets Pastor Jeff involved when Sheldon isn't invited to Billy's birthday party. Also, George Sr. has "male-bonding time" with Dr. Sturgis.

George Sr. and Connie struggle to manage the Cooper household while Mary plans Pastor Jeff’s wedding.

When Sheldon learns the house next door is for sale, he takes it upon himself to find the perfect neighbors. Missy is torn when she’s forced to pitch against her boyfriend at the baseball game.

With college in sight, Sheldon is determined to ride his bike without training wheels. Also, Mary and George Sr. argue over parenting styles.

When their mothers force them to attend Vacation Bible School. Also, George is furious after Georgie makes a questionable purchase.

College orientation does not go as Sheldon planned. Also, Mary is invited to a party when she's mistaken for a university student, and George Sr. helps Pastor Jeff set up a children's nursery.

Sheldon's first day of college is derailed by his new philosophy teacher, Professor Ericson. Also, Mary and Brenda live vicariously through Missy's first day of middle school.

Sheldon, Dr. Linkletter and Connie team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda are spending time together, and Georgie has a new side hustle.

Missy's first heartbreak triggers a series of events that lead the Cooper family to the brink.

Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr.

Sheldon encourages Missy to question the Bible. Also, Connie is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

Sheldon and Dr. Linkletter struggle to solve an equation. Also, Georgie has a solution for Connie's business woes, and George Sr. gives advice on Missy's love life.

Missy asks some uncomfortable questions at church, and Connie and Georgie go into business together.

Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Connie's illegal gambling room.

Sheldon acts as Mary's spy during a youth lock-in at church. Also, Georgie is attracted to an older woman, Mandy.

Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret.

Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

George Sr. bails Connie and Georgie out of jail. Also, Sheldon and Missy meet Mandy, and Mary feels unwelcome at church.

Sheldon's database invention puts him at odds with the university. Also, the church takes issue with Connie's video store.

The gambling room gets broken into and Sheldon wants to study abroad. Also, Missy makes a new friend.

Mandy surprises Georgie with a spa weekend and Sheldon prepares for his summer in Germany.

Sheldon and Mary head to Germany while the rest of the Cooper family braves a tornado that is heading straight for Medford.

News of the tornado reaches Sheldon and Mary in Germany. Also, with the Cooper house in chaos, Missy steps up.

Sheldon helps his roommate try to beat the stock market, Missy and Billy Sparks throw a party, and Mary finds a new church.

Georgie and Mandy's wedding plans pit Mary against Mandy's mom, Audrey, with baby CeeCee caught in the middle.

Connie gets assigned a tough probation officer, and Georgie takes marriage advice from his father-in-law.

The Cooper family grapples with the death of George Cooper Sr.

Sheldon leaves East Texas for the California Institute of Technology following the death of his father.