Jefferson must break the news to his students and faculty that he is stepping down. Struggling with his new life as Painkiller, Kahlil pays a visit to Jennifer in hopes of mending things. Meanwhile, Tobias continues to enact his plan.

Jefferson struggles with the effects on his family, leading to a decision with tragic consequences. Meanwhile, Anissa's identity is threatened. Lastly, Agent Odell takes an important step toward winning over Jennifer.

The war between the 100 and the Kobra Cartel rages on. Meanwhile, Lynn continues to be concerned about Jefferson and Jennifer's curiosity is piqued by a new boy at school.

Jefferson is feeling even more lost after a frustrating therapy session. Meanwhile, Anissa continues to care for a still comatose Grace. Lastly, Lynn has a breakthrough.

The FBI pays Jefferson a visit. Meanwhile, Anissa surprises Grace.