Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.

Believing she's on a winning streak after undergoing a successful kidney transplant, Susan begins to think she's invincible and starts to gamble with the little money she and Mike have, convinced she can't lose. Meanwhile, Bree desperately tries to stop Andrew from admitting to Carlos that he was the one who accidentally killed his mother years ago, and Renee helps introduce Lynette to the world of high class, frivolous shopping now that Tom's bringing in the big bucks with his new, high-powered job. Felicia (guest star Harriet Sansom Harris) moves back into the neighborhood and tries to convince an extremely suspicious Paul that she wants to bury the hatchet and try to be civil to one another.

Gaby covertly meets Bree when Carlos forbids them from being friends after learning the truth about his mother's death. Meanwhile, saved by the late Beth Young's kidney donation, Susan begins to have some inappropriate dreams about Paul; Lynette is reluctant to be the "plus one" when she accompanies Tom to a weekend conference featuring the nation's top executives; and Felicia tries to regain Mrs. McCluskey's trust in her campaign to bring down Paul Young.