Reaching the end of her rope, Bree checks herself into the Fairview psychiatric hospital. Lynette suspects that Tom is cheating on her, so she follows him to Atlantic City. Susan must start over. Felicia Tilman has more in store for Paul Young, resulting in their war reaching its final battle. Gaby and Carlos get Xiao-Mei pregnant.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.