Maisy Gibbons' series of unfortunate events shock the residents of Wisteria Lane when she is finally caught and arrested for prostitution. This leaves unexpected consequences for Bree and Rex when Maisys' little black book becomes public of all her clients.

Gabrielle and Carlos also face a crisis of their own when the sewer system goes out at their house. Also, Lynette braves a scandal herself when it's rumored that the twins started the school's head lice epidemic. Meanwhile, as Susan sinks into depression over her breakup with Mike, she finds a surprising ally.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

Susan professes her love for Ian. Gabrielle and Carlos try to rekindle their love. Bree is confronted with Orson's past. In the meantime, Nora and Lynette go to war.