Five years have passed since Katherine shot her ex-husband as Susan, Lynette, Bree and Gaby stood together in solidarity to protect her. Susan tries to hide her relationship with a new man; Gaby questions her abilities as a mom; Bree is on the verge of publishing her own cookbook as business partner, Katherine, grows envious; Lynette catches her teenaged twins spearheading illegal activities; and Edie returns to Wisteria Lane in jaw-dropping fashion with a new man in tow.

Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism. Meanwhile, Gabrielle and Susan find themselves embroiled in a catfight brought on by an altercation between their kids. To her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things. Finally, Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.

Bree's new found success causes the rest of the women on Wisteria Lane to feel envious. Lynette longs to return to her days as an ad-executive, and finds an outlet as Bree's marketing manager. Mike feels that he is not a big enough presence in his son's life after M.J. draws a family portrait and leaves him out. Meanwhile, Gaby comes up with a way to have more sex with Carlos.

Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday. Jackson wants to take his relationship with Susan to the next level. Gabrielle's concerned she might be pregnant. Tom tells Lynette he's sold the pizzeria. A startling reason for the bond between Bree and Katherine is revealed. And finally, an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

Lynette and Tom uncover the unsettling truth about son Porter. Gabrielle suspects Carlos' best client, Virginia, has ulterior motives. Bree's moment of weakness could bring her great embarrassment and shame. Katherine's not-so-little secret is unveiled. Susan learns of Jackson's true passion. Finally, Mrs. McCluskey's sister Roberta unearths a disturbing fact about Dave.

Susan's daughter Julie comes to visit with her surprising new boyfriend. Gabrielle learns that Mrs. Hildebrand has made her and Carlos heirs of her entire fortune. A reporter looks to expose Bree's imperfections. Lynette learns Porter and Anne Schilling plan to leave Fairview and disappear. Finally, everyone has gathered at a club to see the guys play in the annual "Battle of the Bands" when a fire erupts, threatening the lives of those in attendance. Some will fall as a hero will rise.

For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost. Susan must learn to let go of the man she loves. Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.

Lynette takes extreme measures to protect her son. Carlos realizes the extent of Gaby's sacrifices for their family. Bree wants to prove to Andrew that she has accepted him for who he is. Katherine finds happiness, as Susan and Mike recognize the fate of their relationship. Meanwhile, Dave starts to lose his grip.

Bree clashes with Alex's mother for their sons' affections. Gabrielle urges Carlos to take a six-figure job, even though it means spending more time away from home. Susan turns to Lee for company while Jackson is away. Lynette catches Preston talking to Porter on the phone. Meanwhile, Edie grows weary of Dave, whose strange behavior hasn't abated.

Susan and Edie accidentally lock themselves in a basement; the search for Porter leads Lynette to her mother; Mike and Katherine define their relationship; Dave gets closer to exacting revenge.

When Eli Scruggs (Beau Bridges), the neighborhood handyman, passes away, the residents of Wisteria Lane realize how much he affected their lives.

Susan tries to impress a teacher at work, Gaby talks Carlos into hiring Lynette, Edie continues to look into Dave's past.

Bree contemplates selling her business in order to revive her marriage. Meanwhile, Lynette is threatened at work; Katherine is caught in an unforseen circumstance; and Edie's worst fear begins to come true.

Carlos finds Lynette in a precarious position, which she chooses to hide from Tom, and Gabrielle hastily covers for Tom's coy behavior. Orson tries to hide the truth about his wounds from Bree, while Katherine confesses to Mike, which leads to a surprising realization. In the meantime, Susan confides her dark secret in Dave.

Bree sinks to a new low to retain the best lawyer, and Gabrielle's vanity is put to the test when she makes a deal with her daughter Juanita. Meanwhile, Lynette and Tom negotiate sex, and Katherine deceives Mike to win his heart. Jackson (guest star Gale Harold) walks back into Susan's life with a proposal, and an unexpected visit sends Dave to do some bargaining of his own.

Bree goes to extremes to hide her true intentions from Orson, while Susan and Jackson put on an act for the authorities. Lynette is shocked at the lengths Tom will go to in order to look younger, and Katherine masks the truth from Mike, afraid to lose him. Meanwhile, Dave is on edge when he learns a key witness to his misdeeds surfaces.

Gabrielle becomes upset when Carlos offers to have his not-so-innocent niece, Ana, come and stay with them for a while and disrupts their routine. Meanwhile, Lynette becomes angry at Tom as he desperately tries to hold on to his youth. The brutal battle of the sexes between Orson and Bree gets nasty when Orson discovers what she's been up to. Elsewhere, Detectives Lyons and Collins make headway in the arson fire.

Lynette adapts to Tom's decision to go back to school, Orson takes a beating that Bree cannot comprehend, Gabrielle's niece moves to Wisteria Lane, and Susan and MJ's lives are in grave danger at the hands of Dave.

Mike gets married and his bride is finally revealed will it be Katherine or Susan? Meanwhile, Lynette deals with the realities of being pregnant again; Bree works to break free from Orson; Gaby is tested by Carlos' niece who continues to stay with them; and a new family with dark secrets moves to Wisteria.

Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey's decision to tell the police that she saw Angie Bolen's 19-year-old son, Danny, fighting with Julie.

A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland; Bree contemplates a weekend getaway with Karl; Lynette and Tom break the news to their kids that she's pregnant again; and Susan is convinced Angie's son is responsible for her daughter's attack.

Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John’s intentions towards Ana with twins on the way, Lynette calls upon her family to step up around the house Susan learns Julie has been harboring some secrets and Angie throws a party for son, Danny.

When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent. Bree gets defensive when she’s judged by a motel maid for having an affair with Karl. Lynette is put off by her new handyman when he defers to Tom for approval on all things and Susan and Katherine come to blows over Mike.

Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.

Bree begins to fall for Karl and drifts further from Orson. Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows. Gaby gets Juanita expelled from school. Lynette learns Tom is cheating on his mid-term, and Angie hides the truth about her mother.

Susan believes that Katherine may be Julie's assailant. Angie invites reluctant Bree and Orson to dinner. Gaby struggles to home school Juanita. Lynette has her own suspicions about who attacked Julie. Angie confronts Nick.

In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.

Susan turns up the heat for Mike, Bree learns it won't be easy to undo the hurt she's caused Orson, Lynette discovers Tom's true intentions, and Gaby is forced to examine feelings she's suppressed about her heritage.

Lynette balks at the idea of seeing a couples' therapist. Meanwhile, Katherine is seeing her own psychiatrist, Gaby and Susan are determined to find out which of if their kids are in the smartest group at school, and Angie disapproves of Danny's new girlfriend.

Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.

Having never had the chicken pox herself, Gaby stays with Lee and Bob and is reminded of what it's like to be single again; Lynette and Tom forget Penny's birthday; Bree hires a promising new employee; Susan cheats on Mrs. McKluskey; Katherine makes a surprising discovery and Angie grows concerned over Danny's disappearance.

Angie’s ex-boyfriend, Patrick, emerges after her trip to New York. Meanwhile it’s game on between Gaby and Susan, as they go to shameless lengths to top each other’s kids; Lynette believes there’s more to Preston’s fiancée than she’s letting on; Bree invites Sam over for a family dinner; and Katherine comes out of the closet.

Determined to derail son Preston's marriage to Irina, Lynette discovers the truth about her future daughter-in-law. In the meantime, Gabrielle offers to help out Bob and Lee in the most generous way, but does not consider the consequences. Bree begins to question whether Sam has a hidden agenda, and Susan gets creative to help Mike with his finances. Unbeknownst to Angie, Danny meets Patrick Logan for the very first time.

Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.

Lynette comes to a shocking realization about Eddie. Meanwhile, Angie discreetly relies on Gaby for help when Patrick threatens the life of her son; Bree offers Sam a generous payoff to walk away; and Susan and Mike's financial woes result in the ultimate sacrifice.

Gaby risks her safety to help Angie; Lynette's fate and that of her unborn child lie in the hands of Eddie; Susan comes to grips with her financial woes; Bree considers confessing a secret she's harbored for years; and Angie must submit to Patrick's demands in order to protect her son.

Paul Young, now out of prison, returns to Wisteria Lane with an enigmatic new wife; Susan, Mike and M.J. live in an apartment on limited funds; Lynette's successful college friends pays the Scavos an unexpected visit.

Lynette is angry when Renee starts spending a lot of time with Tom; Bree finds herself falling for Keith (Brian Austin Green); Susan feels guilty about her side job.

Susan is less than pleased when she finds out that some of her best and sexiest internet show moves are being copied by a competitor (guest star Rebecca Creskoff), and Gabrielle hires a private detective to look into an important matter, unbeknownst to Carlos. Meanwhile, Lynette is stunned when Tom's doctor prescribes him a rather unorthodox remedy for his depression, and Renee invites a reluctant Bree to go clubbing with her in order to engage in some local man-hunting.

Susan is horrified when she discovers that she has become the face of the provocative internet company she's been secretly working for and is now the cover model for their outdoor billboard ads; Gabrielle tells her coveted secret to the ladies; Renee finds out that Bree is a grandmother and uses it to her advantage in an attempt to steal Keith away and have him for herself; Lynette takes advantage of daughter Penny's generous offer to help look after the baby; and Paul purchases the home he shared with Mary Alice, against wife Beth's wishes.

Susan is forced to reveal her secret to Mike; Juanita becomes suspicious of Gaby's interest in Grace; Lynette is worried about Tom's mother's memory lapses; Bree learns a secret about Keith; and Paul takes Beth out on a date.

Thanksgiving on Wisteria Lane finds Gabrielle and Carlos hosting Carmen, Hector and Grace to a bountiful feast. But the Solis's discover some surprising news about the Sanchez's that could threaten their time with Grace.

Meanwhile, Bree invites Keith's parents to partake in Thanksgiving at her house and learns some family secrets; Susan butts heads with Lynette over her sleep training techniques for baby Paige; Renee continues to remind Tom about their past; and Beth tries to uncover more about Paul's past misdeeds.

Gabrielle desperately tries to figure out a way to keep Grace in her life; Keith plans a very special dinner with Bree; Tom is angry at Lynette for not disclosing his special attributes to the other ladies; Renee tells Susan a deep, dark secret; and Paul's plan for Wisteria Lane is revealed

Paul's nefarious plan for Wisteria Lane is put into full effect. Juanita discovers that she isn't Gabrielle's biological daughter, and Bree invites Keith (guest star Brian Austin Green) to move in with her, whilst Tom is confronted about his past indiscretion with Renee.

Paul finds out that Beth is Felicia Tilman's daughter while a therapist asks Carlos and Gabrielle to erase Grace from their lives. Susan finds out she needs to go to the hospital every 48 hours and Renee finally tells the secret between her and Tom to Lynette. Orson returns and Bree gets torn apart with her feelings between Orson and Keith and detectives try to find the person responsible for shooting Paul Young.

Susan's mother and aunt visit her at the hospital, Lynette plots revenge against Tom, Gabrielle becomes increasingly obsessed with getting Grace back and Bree wants to be friends with Beth.

Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.

Believing she's on a winning streak after undergoing a successful kidney transplant, Susan begins to think she's invincible and starts to gamble with the little money she and Mike have, convinced she can't lose. Meanwhile, Bree desperately tries to stop Andrew from admitting to Carlos that he was the one who accidentally killed his mother years ago, and Renee helps introduce Lynette to the world of high class, frivolous shopping now that Tom's bringing in the big bucks with his new, high-powered job. Felicia (guest star Harriet Sansom Harris) moves back into the neighborhood and tries to convince an extremely suspicious Paul that she wants to bury the hatchet and try to be civil to one another.

Gaby covertly meets Bree when Carlos forbids them from being friends after learning the truth about his mother's death. Meanwhile, saved by the late Beth Young's kidney donation, Susan begins to have some inappropriate dreams about Paul; Lynette is reluctant to be the "plus one" when she accompanies Tom to a weekend conference featuring the nation's top executives; and Felicia tries to regain Mrs. McCluskey's trust in her campaign to bring down Paul Young.

With Gaby and the girls temporarily staying at Bree's house, Bree must lay down the law and demand discipline before Juanita and Celia destroy her home. Meanwhile Tom hires Lynette and Renee to redecorate his office - but Lynette has her own ideas of what she thinks Tom needs as opposed to wants; and while continuing to help nurse Paul back to health, Susan discovers that Felicia has been released from prison and is back on Wisteria Lane.

Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.

A progressive dinner party thrown for Susan to celebrate her move back onto the lane leads to a shocking murder. Meanwhile, Gaby is stunned to learn the identity of the mysterious man who has been stalking her; Lynette and Tom attempt to put the spark back into their marriage by spending a few days alone together at a romantic Bed & Breakfast; after being placed under arrest for allegedly poisoning Paul, Susan must convince the police that she was being framed for the deed by Felicia; Bree begins to suspect that her new boyfriend may be gay.

While Bree gives Chuck a ride, a smell becomes noticeable; Gabrielle seeks out a priest in order to help Carlos with his problem; Ben Faulkner, a new neighbor, meets Renee; Susan withdraws from her friends because of what happened to Alejandro.

While at a yoga class, Lynette and Renee spy on Jane, Tom's new girlfriend; Gabrielle tries to affect change at a PTA meeting; Bree discovers what Danielle is up to; Susan battles with art class teacher Andre Zeller.

Susan grows suspicious about Amy's affair with Andre; a delivery man tries to deliver a package for Lynette; a man speaks to a sponsor from A.A. about a blackout; the housewives are in the woods with the shovels, but they're being watched.

Bree is stunned when she learns who dug up the body of Gaby's stepfather; jealousy rears its ugly head when Lynette begins to spread untruths to daughter Penny about Tom's new girlfriend; Gaby and Carlos must convince Lee and Bob that Juanita and Celia aren't the bad seeds that they used to be when they want to name them in their will as guardians; and Susan desperately searches her inner self to find what inspires her in order to better her art and impress her hard-to-please art teacher, Andre.

Gabrielle, thinking the worst, goes on a frenzied search for Carlos after he unexpectedly checks out of rehab. Meanwhile, a desolate Bree goes on a drinking binge and finds herself in a desperate situation.

Karen McCluskey finds out about Bree's sex life and interferes, Bree bumps into one of her many conquests unexpectedly, Gabby shares her past with the widow of Alejandro, and after introducing them, Renee ends up paying the price when the date between her hairdresser and Lynette doesn't go well.

Bree's sexual escapades are getting out of hand and help comes from an unexpected source, Susan learns that Julie is pregnant, and Gabby has to deal with a situation at Juanita's school.

Susan discovers the identity of the father of Julie's baby, and Orson makes it his duty to nurse Bree back to health. When Mrs. McCluskey throws Roy out of the house, Gabrielle takes him in and is reluctant to help get them back together when he proves to be an invaluable disciplinarian to her kids. Meanwhile, after getting used to her alone time, Lynette is furious when Porter and Preston are evicted from their apartment and try to move back home, and Mike informs Renee of Ben's dire circumstances with a loan shark.

Susan talks Mike into going to the police when she discovers that Ben's loan shark is out to get him; Mrs. McCluskey, who's dying of cancer, asks Bree to help her commit suicide; Tom's girlfriend, Jane, stuns Lynette at Penny's birthday party; Carlos behaves oddly on his first day back at work, and Gaby is worried.

With Mike gone, Susan attempts to build a car for MJ's father-and-son school soapbox derby; Bree's attorney, Trip, learns of her previous drunken sexual spree and needs her to come clean about it in order to help strengthen her case; Lynette tries to cause some negative friction between Tom and his girlfriend, Jane, by flirting with his boss and getting him to pile more work on her estranged husband; Gaby is furious with Carlos when he tries to poach one of her rich, personal shopper clients (Doris Roberts) and talk her into helping with his newly formed charity organization; and Renee discovers that Ben is keeping a secret from her about his involvement with Bree -- and the body found at his work site.

In the penultimate episode leading into the two-hour finale of this landmark series, as her trial nears, Bree begins to fall for her attorney, Trip; Susan becomes concerned when Julie doubts Porter's commitment to be a hands-on father to their unborn baby; as Tom gets closer to being transferred to India for his job - thanks to Lynette - she begins to have second thoughts and tries to convince his boss to rescind the move; and the ladies are shocked about Gaby's nonchalant attitude as Bree continues to stand trial and take the fall for Carlos in the murder of Alejandro.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.