John awakens to find himself stranded on an island off Seattle. His uncanny abilities are soon apparent to him when he is rescued by Asian fishermen and begins to speak the sailors' language fluently. When he sees a news report about a kidnapped girl, the color-blind Doe realizes that he is seeing the child in color. Sure that she holds the key to the mystery of who he is, Doe is eager to find her and offers his assistance to the skeptical police.

John is hit by lightning on his chest-brand and can see in color — going to see a fresh body, John realizes he's also lost access to his vast supply of knowledge and all the physical talents it provided. It's not a good time as a killer strikes, leaving a kidney from his victim with the promise of more to come. The killer strikes again with two killings as John tries to come to terms with his newfound ignorance and the loss of his money when he can't call the shots for his broker. John is bitter and reluctant to admit his newfound loss to anyone, and a disappointed killer threatens to come after him. It turns out that two women, sisters, are working as the killers and lure John into a trap — fortunately John figured the killer(s) were women and he'd be targeted and the police have him wired and are watching. While pursuing one of the killers John is hit with electricity again and is back to being color-blind and super-smart.