An airborne contamination alert locks down the West Wing, forcing staffers to stay put until the all-clear is sounded; Toby and Will face off over Will's working for the vice president; C.J. tells Donna some things she's rather not hear about Josh and her career prospects; Leo confronts Abbey about the dangers of her recent coping mechanisms; Jed, Debbie, and Charlie are poked, prodded, and sent to the decontamination showers; Kate is initially reluctant to give Josh any information on a personal or professional level as they sit out the alert together.

Penn and Teller roll a lesson about the First Amendment into their entertainment at Zoey's White House birthday party, setting off a media frenzy and public relations nightmare; Baker drops out of the race, leaving the field free for Russell, who asks Josh to run his campaign; Jed takes a hard line on making significant gains on substantive issues in his last China summit; Vinick turns down Jed's offer of the U.N. ambassadorship to run for president; a fully ambulatory Donna has difficulty scheduling a meeting with Josh; Jed has an MS relapse which leaves him partially paralyzed and in a wheelchair.