Bryan Mills fights for his life inside a secret Mexican prison and plans a series of dangerous deals to put him on track for escape to the United States. But plans change when Mills and a young migrant girl are taken by human traffickers. Meanwhile, Christina Hart leverages her spycraft skills to obtain powerful new software that could locate Mills, and enlists two unlikely allies to aid in her mission to bring Mills home.

When a plane crashes carrying Bryan Mills and a key witness in a murder investigation, a wounded Mills must call upon the survival skills his father taught him to overcome the elements, find a way out of the woods and protect the witness from a lethal team of mercenaries on their tail. Meanwhile, Santana organizes a 'go big or go home' plan to locate the downed plane.

A laid-off worker kidnaps a high-powered accountant in revenge for his lost pension, and the team gets swept up in a case of class warfare when Bryan decides to help the kidnapper get justice.

When the President's emergency "football" is stolen, Bryan and the team must recover it before classified national security measures fall into dangerous hands.

Santana must face her past when a foreign diplomat linked to a sex trafficking ring is kidnapped.

Bryan and Santana must extract a nuclear physicist long thought dead, from a secret North Korean prison compound. Meanwhile, Kilroy faces a moral dilemma when Hart asks him to locate a criminal wanted by a foreign government.

Hart takes a solo mission to track down the mentor who betrayed her, and the team tries to locate her before it's too late.

Bryan must stop an act of biological terrorism when invasive species are stolen from the Global Seed Bank in Norway.

With Hart in grave danger, the team must find their own way to stop Ramsey before his plan to assassinate a senator starts a war with international terrorists.