Multiple stabbings, suicide attempts, a double shooting and an explosion at a flat flood the control centre of the London Ambulance Service with emergency calls threatening to overwhelm the service.

We join the staff in the nerve-centre control room on the night shift. Amongst the thousands of calls they receive, they also have to contend with hoaxers, frequent callers and run-away patients.

The staff of the London Ambulance Service prepare for another busy weekend. Amidst the call-outs to drunken fights, drug overdoses and stabbings there are also five women going into labour and a miscarriage to cope with.

It is Saturday night and Katie and Sarah race to help a man who has collapsed at home. By midnight, revellers spilling out of bars and clubs start to impact the service as calls flood in of brawls and accidents.

1 hour into the night-shift the control centre is already onto its 3rd cardiac arrest and the 12th stabbing victim of the weekend. Other crews are tied up caring for an alcoholic and an elderly man.

A crew are dispatched to attend to a woman complaining of stomach pains, but she has actually suffered a massive heart attack. Terminal cancer patient Nigel is philosophical about his life.

Jo and Suki are involved in high drama as they take a patient to hospital when a car crashes right in front of them. Call-handlers deal with two suicidal patients. In Birmingham a woman has had her finger bitten off.

The air ambulance is dispatched to a woman struggling to breathe after falling, but the helicopter is soon also needed at a road accident in Staffordshire. Reports of a hanging come in but is the call a hoax?

Justin and Dawn's first call of the day is to a woman whose waters have broken. A drunken man, repeat callers and a woman unable to leave her home all test the crews patience.

Crews in the more rural areas covered by the service are called out to an elderly couple, a train-spotter who has fallen and banged his head and suicidal patients.

The West Midlands Ambulance Service have to deal with the fatal consequences as Storm Doris batters the UK. Gale force winds are causing accidents, blocking roads and grounding the air ambulance.