Disgraced heart surgeon Dr Hugh Knight's plans to leave Whyhope forever are upended when tragedy strikes. Penny makes a fateful decision about her love-life.

Meryl and Carlito’s relationship sends shock waves through the Knight family. Tension between Hugh and Penny puts the new cardiac clinic at risk. Matt reconnects with his old high school crush.

Penny's personal feelings for Hugh spill over into the workplace, with embarrassing results. Charlie and Matt struggle to deal with an unwanted house guest. A high-profile cardiac patient causes problems for Ken and Hugh.