前軍情六處特工羅斯·泰勒招募鳳凰基金會前成員麥克、萊利、博茲、馬蒂和德西去追捕一種生物武器，該生物武器計畫被一個神祕組織用於對美國一個主要城市的毀滅性襲擊。

美国国防部将军约翰阿科斯塔（John Acosta）招募麦吉弗（MacGyver）从一个军事实验室窃取一个高度机密的项目，以发现其安全漏洞。但当发现将军计划使用武器发动攻击时，菲尼克斯必须在武器上传前阻止阿科斯塔。

当飞行员心脏病发作时，麦基弗和他的团队登上了一架正在飞行途中的飞机，发现这起医疗事故是故意的。

当麦基弗迅速从德国一座倒塌的建筑中营救幸存者时，他发现了一个新的安全威胁——一枚隐藏在废墟下的二战遗留下来的1000磅重的未爆炸物。

为了在法典中找到主要球员，并切断他们的假球资金，德西卧底潜入一支足球队，并找到与影子组织合作的腐败球员。

当鲁斯的初恋情人埃米利娅被他在私人军事合同时期与之战斗过的叛军绑架时，他带着凤凰队来到一个贫穷的小镇去营救她，让小镇永远摆脱叛军。

A double date descends into chaos when Mac and Desi witness a murder in the back of the restaurant, and as they work to find the killer, Riley tries to keep the secret about her and her friends’ “day jobs” from her new boyfriend, Aubrey.

After Oversight is almost killed in a bombing, he recruits Mac to help him find the suspected bomber, Mason. However, when Mason reveals he didn’t plant the bomb, the three team up to track down Codex, the shadow organization that set them up. Also, Mac meets his aunt Gwendolyn.

While Mac’s friends surround him during his time of grief, Los Angeles’ power grid is taken hostage in a ransomware attack resulting in a citywide blackout, and the team discovers the code used was written by Riley years ago

When Mac is put into a dream state to help him recall key evidence found in Nikola Tesla’s secret lab that could stop Codex’s deadly plot, he encounters Nikola Tesla, Alexander Graham Bell, Thomas Edison…and his mother.

Mac is placed inside a fake prison cell with a top Codex operative, The Merchant, in order to gain his trust and get intel on their next move.

The Phoenix team is forever altered when MacGyver’s Aunt Gwen gets into his head about family and connection and convinces Mac and Riley to join Codex. Also, Matty and Russ take their concerns about Codex to the White House.

With Mac and Riley undercover with Codex, hoping to stop the organization from within, their mission is interrupted when Russ, Desi and the Phoenix team move to prevent Codex from detonating a weapon of mass destruction, with Mac and Riley caught in the crosshairs. Also, the team discovers Russ’ real reason for purchasing the Phoenix Foundation.

Mac and the team infiltrate a glamorous hotel used as an international hideout for criminals to find a woman with vital information on Codex. However, their target has a new secret identity, including a completely new face.

When Taylor’s former protégé is killed while preventing a bio-weapon from falling into the wrong hands, Mac and the team must find the weapon so Desi can pull off the ultimate heist before it’s sold to a terrorist cell.

When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues.

Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Also, Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped.

Using a cryptic postcard as their only clue, Mac and the team must solve a fallen friend’s final case and bring him justice.

During COVID-19’s first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor’s house. Also, Russ’ romantic fling takes on a longer and more complicated turn when they quarantine together.

The secret experimental cancer treatment Mac’s developing with a friend is discovered when culprits ransack their lab, kidnap Mac’s partner and plan to use the research to create a powerful new nerve agent.

Mac and team rush to help when Matty’s former mentor, Ian Cain, and his embassy staff come down with a deadly, mysterious illness. Taylor and Bozer work with Jerry Ortega to infiltrate a Codex cell.

When Mac and the team are unable to prevent Department of Defense intel from falling into Codex’s hands, Mac must scale a vertical cliff using only gear he can cobble together himself to prevent the info’s transmission.

While on a mission to hunt down a Codex lead, Mac and the team discover Murdoc hacked their comms and has recorded them for months. Now, Mac and the team must stop Murdoc, who is working with Andrews, as they plot to kill thousands and reveal each Phoenix member’s most-guarded secrets.

Mac and Riley head overseas together to prevent a governmental collapse and inadvertently inhale new deadly microscopic technology.

Mac, Desi and Russ go undercover during a royal Indian wedding to protect a princess whose policies could put her life in danger. Also, Russ and Sophia come face-to-face at the wedding, Bozer suspects Riley is up to her old hacking ways and Matty runs down a lead in hopes of getting to the bottom of Mac and Riley’s ingested nano-trackers,

While Mac and the team delve into the world of Italian car culture in order to track down a crime boss-in-hiding, Mac must lean on Desi when he discovers that he losing the ability to control his hands. Also, Mac and Desi move in together and Riley reveals the truth about her secret team of hackers to Russ.

Mac and Desi travel with Bozer to his childhood home when his aunt dies in a tragic accident, however, they soon discover she may have been murdered for trying to expose the city’s contaminated water supply. Also, Riley, Matty and Russ continue to follow leads on their nano-trackers investigation.

When Mac and Riley go missing and wake up 24 hours later in a corn field with no memory of how they got there, they must unravel the mystery to find who took them, and how to get rid of the nanotrackers in their bodies, no matter the cost.