President Kirkman is faced with a viral pandemic that threatens to kill countless Americans. Hannah and Damian discover evidence that could change the lives of members of the first family forever.

While on a secret mission to Afghanistan, President Kirkman meets with two infamous warlords and must determine whom he can trust to hand over territories to the U.S., while Seth has a run-in with Washington, D.C., police that puts his job, reputation and future in the White House on the line.