Vanessa’s past rushes back to confront her in an unexpected way; a secret that Doc has been protecting is revealed; and in a bid to bolster his power, Dmitri sends Scab on an impossible mission.

Vanessa faces off with Dmitri; Axel fights against becoming a full-fledged vampire; Sam tracks Mohamad, Flesh and Lucky; Scab tries to enlist a fierce group of vampires to join Dmitri.

As the group struggles with the disappearance of one of its own, they accept sanctuary in a town run by its Sheriff and his troops; Dmitri inches closer to achieving his darkest goal.

A tense standoff between law enforcement and the survivors erupts into a bloodbath; in a bid to evade a vicious breed of vampire, Axel and Scarlett find themselves hunted like prey.

While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe; Doc makes a medical discovery that could change everything.

At a mountain stronghold, secrets of the Van Helsing family are unearthed and the true face of evil is exposed; a climactic battle between humans and vampires leaves humanity's fate in question.

Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.

To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.

In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces. In Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.

Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.

On a distant island, Vanessa and Scarlett battle the Third Elder; Vanessa makes a choice about her path forward, one that Scarlett does not agree with.

Scarlett is reunited with Axel but he is badly injured before they can find Vanessa. A mysterious man helps them find their way. Flesh and Jolene are fugitives on the run from Blaktek.

Vanessa and Sam face off to find the Last Elder, with Scarlett, Axel and Mohamad caught in the crossfire.

Vanessa wills Axel into The Dark Realm where they both discover secrets of their past that may help them in the future.