While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.

An investigation into the death of a Miami model the night after her beachfront photo shoot leads Rosie and Villa into the world of plastic surgery.

Rosie, Villa and TMI head to a small town to investigate the murder of its former mayor. Rosie struggles with feelings of guilt, as Slade faces complications following his kidney donation