As tensions reach a fever pitch inside the cordon, mobs of angry protestors take to the streets in an attempt to break free. Meanwhile, stuck in isolation and cut off from their chain of command, Lex and Dr. Lommers have no choice but to stand by helplessly as the cordon erupts into mass chaos. At the hospital, Jake attempts to lighten the mood by taking Katie on a date, but their happiness is short-lived after they discover that several of Katie’s students have gone missing. Meanwhile, with Lex nowhere to be found, Leo moves forward with their investigation, inching one step closer to uncovering the person responsible for the outbreak.

Lex and Leo clash over their next move after a failed plan threatens to unravel their entire case. When word begins to spread that there may be a way out of the cordon, Jana considers her options. Finally, an unexpected turn of events brings Jake and Katie closer than ever.