Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

When her former patient returns to Med, Goodwin learns that time doesn't heal all wounds. Frost and Charles treat a patient struggling with his sexuality. Lenox and Abrams work to save a woman who has been in a coma for 20 years.

The hospital faces a staffing crisis as the nurses stage a sick-out. Archer and Frost bet on who can discharge their patients first. Charles' distrust of a patient complicates his treatment.

Maggie and Frost fight to get a pair of lungs for a young cystic fibrosis patient. Asher learns whether she can become a surrogate. Ripley and Morris treat a tech billionaire's daughter as she battles leukemia.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.