When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers an extremely rare condition in her patient's ultrasound.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.