Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

The crossover starts on Chicago Fire S08E04 Infection (I). It continues on Chicago PD S07E04 Infection, Part III (III).

In the aftermath of the Vas-COM scandal, Goodwin clashes with the hospital’s new compliance officer. Crockett and Blake try to save a patient who has a son with severe autism. A patient’s son lies to his father about his diagnosis.