Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer’s is brought into the E.D. Maggie and Ben become concerned when one of Ben’s students is admitted. Dr. Manning and Dr. Marcel treat a terminally ill patient and disagree over the best course of action.

Dr. Charles evaluates a 15-year old who is brought into the E.D. after an apparent fall off an overpass. Will sides with Dr. Asher on a risky treatment plan. Tensions run high between Dr. Choi and Dr. Marcel.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.