After the death of her husband, Cassie Nightingale and her family find themselves caring for her ailing father-in-law. Moving in next door are the Radfords, Sam and Nick. Sam, the town's new doctor, has difficulty getting patients, as the town goes to Cassie's store for her more earthly herbal remedies.

Trouble is brewing after Cassie's mystery guest Ashley goes missing, and another pair of visitors to Middleton shake things up just in time for the town's annual heritage ball.