While out star-gazing, the gang meets the cosmonaut monkey Boris (Greg Baldwin), having crash-landed into the jungle. Though his shuttle comes equipped with a rescue signal button, he refuses to push it and have the humans return him to space. While Brandy schemes to call for her own rescue, Mr. Whiskers is having fun playing spaceman and thwarting her.

When Mr. Whiskers finds out about luck, he believes his feet will provide him with the luck he needs to remain safe and get anything he wants, much to Brandy’s dismay.

When Brandy tells Mr. Whiskers to read something because he has too much time on his hands, she inadvertently leaves her Diary out in the open, in which Mr. Whiskers reads because of her suggestion. After a while he starts to read everyone else's diaries, too. In the end, Whiskers gets tied upside down as punishment while Brandy befriends the spider who has about to devour him.

While enjoying themselves at the river, Mr. Whiskers inadvertently crashes into Ed after Ed crashes into a log, which causes Mr. Whiskers to fly into a Mayan temple. Inside, they discover an ancient monkey's paw that grants wishes, in which Brandy decides to use to get back home; though the ancient artifact is much different than they anticipated.

Brandy and Mr. Whiskers find a baby Tapir after their picnic gets ruined. Brandy decides to take care of the baby until they can find its parents and she leaves the baby in Mr. Whiskers' care until she can find out more about the child. However, when the baby begins to look at Mr. Whiskers for a role model, Brandy is upset because Mr. Whiskers doesn't grasp the concept and begins to teach the Tapir some poor behavioral choices.

When Mr. Whiskers falls out of the tree for yet another time, Brandy insults him, saying that he never uses his brain. However, Mr. Whiskers' brain agrees with her, so he decides to leave his brain and head off to live his own life. Mr. Whiskers begins to become depressed as he feels lonely without his brain inside of his head, so Brandy decides to head off to find Mr. Whiskers' brain in order to return it to the rightful place where it belongs, though how will she manage to convince his brain to go back to the place he hates?

Brandy has had her eye on an attractive marsh deer named Melvin for quite some time, though when he refuses to talk to her, Brandy begins to wonder if there's something wrong with her physical appearance. When Gaspar shows up and offers her some teeth whitening merchandise, she accepts his offer and she begins to undergo procedures to make he

Mr. Whiskers is excited because there is an audition taking place for a play in the Amazon, though his comments on the subject causes Brandy to decide to enter as well. However, when Margo sabotages Brandy's audition by messing with her drink, Brandy only manages to become the understudy while Margo gets the main role; though Gaspar makes a proposal to Brandy that may just help her get the position that she feels she deserved.

After Whiskers thinks he has been bitten by a frog that can make victims sleep for 50 years and decides to do a lot of things with Brandy including "kiss a preety girl". When Brandy finds out she's the girl to kiss, and the frog that Whiskers had been bitten by has to convince Whiskers the truth.