Cookie and Lucious push to get back in the music game, but they'll need the whole family and some old allies to make serious sacrifices in order to do so. Meanwhile, Andre finds a risky way to make a name for himself among his fellow inmates.

With the reputation of the family business on the line, the Lyons strategize on how to clean up Kingsley's mess and introduce a new and improved Empire. As Lucious and Cookie hire an old acquaintance to help track down the money Eddie stole, Andre tries to convince Devon's record label to let him record with Empire. Meanwhile, Treasure and Tiana fight for the female vocalist track on Jamal's new song.

The Lyons' world is turned upside down as they face a loss, which forces one Lyon to deal with an unresolved trauma from the past. Meanwhile, Andre makes an important decision about his health, family and career and Devon confronts Tiana about her relationship with Hakeem. Also, a shocking revelation about the future of the Lyons is revealed.

After witnessing Andre's breakdown, Cookie and Lucious have him committed to the same treatment facility as Leah and the guilt Cookie feels from Andre's situation causes her to wonder how different life would be if she had not gone to prison. Meanwhile, Becky struggles with balancing her personal and professional relationships and Hakeem and Maya find themselves in a less-than-ideal situation after a drunken night in Vegas.