Lucious Lyon is the head of a music empire whose reign has been unchallenged for years. But all that changes when he learns he has a disease and must choose one of his three sons to take over: Andre, Jamal or Hakeem. Complicating matters is their mother and Lucious’ ex-wife, Cookie, who emerges from prison to claim her share.

Lucious has to defend Empire's IPO launch after one of his artists is involved in a shooting; Cookie hears about Lucious' plans for a huge performance for Hakeem, but not Jamal; Bunkie's murder is investigated.

Still in federal lockup, Lucious is trying to run Empire from inside, while a headline-grabbing state prosecutor hangs her political ambitions on bringing him down - no matter what it takes. Meanwhile, Cookie stages a star-studded #FreeLucious concert in his support, while scheming with Andre, Hakeem, Anika and the business savvy Mimi Whiteman to finalize the hostile takeover of Empire.