Beautiful, athletic, and trained as highly skilled assassins, Kitana and Mileena have grown up thinking that they are sisters. Shao Kahn, Emperor of the Outworld, has tricked Shang Tsung into becoming his servant for Mortal Kombat by making him clone Mileena as a Tarkatan clone of Kitana, out of Shao Kahn's fear that Kitana wouldn't love him enough if she ever found out the truth about her Mother and Father.

The rivalry between Kitana and Mileena grows, while Kitana attempts to learn the truth behind her childhood and the real identity of her parents.