When the President approves Henry's reactivation into the NSA, he decides to keep his continued involvement in the spy game a secret from Elizabeth. Meanwhile, Matt and Daisy's antagonism toward one another begins to affect the entire office.

While Elizabeth seeks a diplomatic solution to a doomsday cult in Bolivia, a congressman attempting to negotiate with its leader is taken hostage. Meanwhile, Elizabeth and Henry meet Stevie’s much older boyfriend.

When President Dalton gets word that the world’s most wanted terrorist, Jibral Disah, is hiding in Islamabad, he sends the “Murphy Station” – Henry, Jane and Jose – on a dangerous mission to eliminate the threat. Also, Elizabeth and Henry go to couples therapy.

The United States debates enacting a “render safe” mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disah.

When an imminent U.S.-France state dinner is jeopardized after a CIA operative is captured by French intelligence, Elizabeth must negotiate the operative’s release while keeping the event on track.

As President Dalton eagerly awaits voting results on Election Day, Elizabeth uncovers information that could put the U.S.’s peace deal with Iran in jeopardy.

When a possible Israel-Iran war threatens the House’s imminent vote on the U.S. presidential election, Elizabeth attempts to bring the two reluctant countries to the negotiation table in an effort to broker a peace between them. Also, Russell’s life hangs in the balance after a heart attack.

As the U.S. hunts for the person believed to be behind the CIA arms smuggling case, Elizabeth and her team must work to save Jay when he’s kidnapped in Nice, France, during a fact-finding mission into the suspect. Also, Henry suspects the doomsday cult is planning an attack in Israel, and Jason dupes his parents into giving him money for an expensive calculator when he’s really using it to impress a girl.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.

Elizabeth heads to Brussels to seek NATO’s support against Russia when it threatens to invade Bulgaria, but when France refuses to cooperate, it could threaten the alliance’s very existence. Also, Henry’s new government role has him dive into the Russia issue and turn to his former operative, Dmitri Petrov for help, and as Nadine and Mike B’s relationship heats up, Elizabeth finds out information about her old friend that makes her question his loyalties.

Henry disagrees with the President and Elizabeth when they refuse to negotiate with terrorists for the release of an American CIA agent who was captured by the Taliban in Afghanistan. Also, Elizabeth tries to be supportive of Stevie who is going through a difficult time.

Secretary of State McCord and her staff work with the Mexican government to extradite a Mexican cartel leader to a U.S. prison in an effort to diminish the opioid crisis. But after he escapes during transport and a journalist who secured a gloating interview with him while on the lam is murdered, Elizabeth’s urgency to find the leader escalates.