The President’s plane is declared missing and Elizabeth is thrust into a situation of power she never imagined possible. Also, Henry butts heads with his new Defense Intelligence Agency handler, Jane Fellows, when he’s asked to recruit one of his Russian students for the NSA.

Elizabeth and President Dalton’s administration are met with hostility while trying to deal with the Russian government. Also, Dmitri is kidnapped and interrogated about being a Russian spy.

Elizabeth finds herself pushed out of the President's inner circle after she disagrees with his response to the growing tension with Russia. Also, when incriminating photos of Stevie and Harrison surface, Elizabeth and Henry must deal with the aftermath and try to protect their daughter from the media.

As tensions rise with Russia, Elizabeth, Russell and Mike B. hatch a plan to oust National Security Advisor Craig Sterling without tarnishing President Dalton with a scandal. Director of National Intelligence Ephraim Ware identifies who hacked Air Force One.

Shortly before Elizabeth is to deliver a speech at the United Nations accusing Russia for the attack on Air Force One, Henry shares information that makes her reconsider her theory.

As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.

The United States debates enacting a “render safe” mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disah.

When a storm destroys a naval base in Bahrain, Elizabeth urges President Dalton to reexamine his approach to climate change and his overall foreign policy, something that could jeopardize his re-election campaign. Also, the McCords worry that their family is being stalked when they discover Jason’s laptop may have been hacked.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.