27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

Cole and Railly attempt a final confrontation with their closest enemies, while Jones faces a new threat to all that she's accomplished.

Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.