Cole's search for the location of the virus leads him to 2014, and to a devastating moment in Dr. Railly's life involving a dangerous outbreak in Haiti.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room –- an off-site, black ops lab that houses the virus that will one day destroy the world.

Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

When all hope is lost, Cole must complete his cycle so that his younger self will one day arrive at the end with the answer.