Drew and Paul head to the scene of a multi-car collision while the newly-anointed Dr. Ragosa along with Jordan, Scott, Krista and Kenny, manage the deluge of incoming victims. Meanwhile, TC and Topher head into a war zone to treat an old friend.

T.C. and Topher return to find Jordan in critical condition and San Antonio terrorized by snipers; Drew and Gwen get caught in the crossfire when a SWAT team corners the snipers.

TC initiates a bar brawl, landing him and Drew in jail for the night. While behind bars, Drew and TC's relationship reaches a breaking point. Jordan rushes her date to the ER, where she's shocked to learn he's not who she thought he was. Topher fights for a patient who many doctors have dismissed. Scott and Annie struggle to save their relationship while Jessica works to win back TC's trust. Meanwhile, Syd meets Brianna, and Rick visits the hospital.

Drew, his mom, and Rick's flight home turns into a medical crisis at 35,000 feet when passengers become sickened one by one. Jordan, Paul, Shannon, Kenny, and Cain spend their day off at an obstacle course fundraiser for Cystic Fibrosis, hosted by Akbar Gbajabjamila. Scott finds himself on a Tinder date he won't soon forget. Meanwhile, TC puts his own life in danger to operate on a soldier.

When Jordan realizes the hospital is under cyber-attack, she leads the team in managing patient care as chaos ensues. Drew and Kenny treat a critical patient forcing Drew to call on his medical and military training. TC joins Rick and his partner on a SWAT drug raid. Meanwhile, he wrestles with whether or not he should return to Syria to tie up loose ends.

A shooting at a nearby college sends TC, Jordan, Drew and Amira into the field, where they assist Rick with a deadly situation. Scott implements a new training program and locks horns with Julian. Drew struggles with frustrations about going to Army Ranger School while Shannon and TC both contemplate their future at San Antonio Memorial.