Constantine has checked himself into Ravenscar Asylum following the loss of a 9-year-old girl, Astra to the demon Nergal. The loss of her soul, along with his own, has been tormenting him. Naturally, he'll have to snap out of it. That moment comes six months later when a possessing spirit sends him a disturbing message. John is on a mission to save the daughter of a friend who is being targeted by a demonic antagonist.

Manny sends John to help an old friend, Ritchie Simpson, at Ivy University. There a group of students have found a way into an alternate dimension, only to be met by a maniacal killer.