With the deadly virus spreading throughout the city, the search for the antidote continues, as Fish Mooney, The Riddler and Penguin reveal plans of their own. Bruce meets Ra's al Ghul and completes his last task in order to fulfill his destiny, but realizes he can't let go of his past. Meanwhile, Gordon tries to win back Lee, and past alliances within Gotham City are broken, while new alliances are formed.

Gordon and Bullock investigate a location where several kids have been kidnapped. Barbara proves to be an unlikely ally to Gordon. Bruce looks into an alleged witch with healing powers for Selina. Nygma deals with demons of his own.