The Powerpuff Girls hate roaches. Roach Coach uses this to his advantage to take over Townsville. Can the Powerpuff Girls overcome their fear of roaches?

After receiving a dollar from the Professor, Buttercup gets hooked and steals other people's teeth for the tooth fairy.

Mojo Jojo, Princess Morebucks, Fuzzy Lumpkins, and Him all team up as The Beat Alls to defeat the Powerpuff Girls. All is going well until Mojo Jojo falls in love with Moko Jono who breaks up the Beat Alls.

The Powerpuff Girls try to stop the villains of Townsville from obtaining the Key to the World, which actually gives its possessor the right to rule the world.