Det. Reno Raines becomes a fugitive from justice when his investigation of illicit police activity leads a corrupt lieutenant to frame him for murder.

A bullet that was meant for Reno critically injured his girlfriend Valerie instead. After spending months in coma, she is finally released from her suffering. The criminal lieutenant Donald "Dutch" Dixon places a trap for Reno: He lets spreads the news that Valerie is healed.

The daughter of Reno's loyal long-time friend Assistant D. A. Wells begins going on a downhill spiral, entering a life of drug addiction. Upon further investigation, Reno and Cheyenne discover there is much more to this family tragedy than originally thought. They soon uncover a rather elaborate scheme involving black market drugs, a touring rock band, and a corrupt band manager who plans to use the girl to leverage Wells into dropping the impending case against her brother, a notorious drug dealer.